© 2018 International Society for Magnetic Resonance in Medicine.Īdditional Supporting Information may be found in the online version of this article. The implications for research into eye diseases including ocular melanoma, cataract, and glaucoma are discussed. Our results provide encouragement for further clinical studies. Three most important eye compartments in the context of sodium physiology were clearly delineated in all of the images: the vitreous humor, the aqueous humor, and the lens.
High spatial resolution (nominal 1.4 and 1.0 mm isotropic) sodium in vivo images of the human eye were acquired within scan times suitable for clinical applications (∼ 10 min). Our radiofrequency coil is light and conforms to an average human head. The specific absorption ratio simulations confirm that the radiofrequency coil is safe for clinical use. Measured transmit field distribution agrees well with the one obtained from simulations. An in vivo feasibility study was carried out with 3-dimensional density-adapted projection reconstruction imaging technique. Transmit field mapping was conducted using a phase-sensitive method. Transmit field uniformity was optimized by using a multi-objective genetic algorithm. MethodsĮlectromagnetic field and specific absorption ratio simulations were performed.
We present a detailed description of the radiofrequency coil design, along with electromagnetic field and specific absorption ratio simulations, data validation, and in vivo application. The aim of this study was to achieve millimeter spatial resolution sodium in vivo MRI of the human eye at 7 T using a dedicated six-channel transceiver array.
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